HYBRID CYTOKINE WITH PARTS FROM AT LEAST 2 OF LEUKAEMIA INHIBITORY FACTOR (LIF), GRANULOCYTE-COLONY STIMULATING FACTOR (G-CSF), INTERLEUKIN-6 AND ONCOSTATIN-M

摘要

Hybrid cytokines containing four helical regions, each of which is derived from a corresponding alpha-helical region in leukemia inhibitory factor (LIF), granulocyte colony stimulating factor (G-CSF), interleukin-6 (IL-6) or oncostatin-M (OSM) are disclosed. These hybrid cytokines may further contain linking regions also derived from corresponding linking regions in these factors. The hybrid cytokines offer a unique spectrum of activities useful in treating conditions for which the native cytokines are useful or in treating conditions characterized by an excess of the native cytokines.