ONE-STEP PROCESS FOR THE PRODUCTION OF CRYSTALLINE DIRITHROMYCIN (AN ERYTHROMYCIN DERIVATIVE) FROM AN ACETAL AND ERYTHROMYCYLAMINE

摘要

The disclosure relates to a new process for the synthesis of the macrolide antibiotic dirithromycin in crystalline form. The process is carried out in a single reaction vessel whereby an acetal dissolved in acetonitrile, in the presence of an acid catalyst, is hydrolyzed to the related hemiacetal which then reacts directly with erythromycylamine to form crystalline dirithromycin.