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METHOD OF OBTAINING A PERCUTANEOUS THERAPEUTIC SYSTEM CONTAINING BUPERNOPHYNE AS AN ACTIVE SUBSTANCE
METHOD OF OBTAINING A PERCUTANEOUS THERAPEUTIC SYSTEM CONTAINING BUPERNOPHYNE AS AN ACTIVE SUBSTANCE
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机译:获得含有紫茎菜碱作为活性物质的皮肤治疗系统的方法
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摘要
The controlled delivery of buprenorphine or its pharmaceutically compatible salts over at least 24 hours onto the skin is ensured by a transdermal therapeutic system composed of a backing layer which is impermeable to active substance, of an adhesive reservoir layer and, where appropriate, of a protective layer which can be detached again, which system is characterised in that the reservoir layer contains 20-90% by weight of polymeric material, 0.1-30% by weight of plasticiser, 0.1-20% of buprenorphine base or of one of its pharmaceutically acceptable salts and 0.1-30% by weight of solvent for the active substance base.
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