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PROCESS FOR THE PREPARATION OF AN ORAL PHARMACEUTICAL COMPOSITION OF MULTIPLE UNITS OF CONTROLLED LIBERATION
PROCESS FOR THE PREPARATION OF AN ORAL PHARMACEUTICAL COMPOSITION OF MULTIPLE UNITS OF CONTROLLED LIBERATION
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机译:多单位受控解放的口腔药物组合物的制备方法
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摘要
The invention relates to an oral pharmaceutical multiple units formulation comprising individual cores containing a pharmacologically active substance, said cores being provided with a coating consisting essentially of a polymer, that is insoluble in, impermeable to and non-soluble in water and in gastrointestinal fluids, and a watersoluble pore-creating substance, which is randomly distributed in said polymer, whereby said coated cores form units providing an essential zero order diffusion controlled release rate of said active substance. The invention also comprises a method of preparing these formulations.
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