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GONADOLIBERIN ANALOGS WITH INCREASED SOLUBILITY METHOD OF THEIR PRODUCTION, AGENTS WITH THEIR CONTENTS AND THEIR USING
GONADOLIBERIN ANALOGS WITH INCREASED SOLUBILITY METHOD OF THEIR PRODUCTION, AGENTS WITH THEIR CONTENTS AND THEIR USING
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机译:产量增加的溶解度模拟物降钙素原类似物及其含量的试剂及其用途
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摘要
The invention relates to peptides of the formula IMAGE in which X is absent or is hydrogen or acyl; A is Pgl, de-hydro-Pro, Pro, D-Thi or D-Pgl or represents optionally substituted D-Nal(2), D-Phe or D-Trp; B is His or optionally substituted D-Phe; C is Trp, D-Thi, D-Pal(3) or optionally substituted D-Trp; D is Tyr, Arg of His; E is D-Ser(R1), beta -Asn, beta -Asp-OMe, D-Thi or -NH-CH(CH2R2)-CO-; F is Ser(R1), Leu, Trp or Phe; G is Gly-NH2, Aza-Gly-NH2, D-Ala-NH2 or NH-alkyl; R1 is glycosyl and R2 is hydrogen, acyl, aryl or heteroaryl. The invention also relates to methods for the preparation of these peptides, agents containing them and their use.
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