Alkanediamine derivatives and their use in the treatment of arrhythmia and ischaemic rhythm disorders

摘要

A compound of formula (I) or a salt thereof, or a solvate thereof, wherein A and B each independently represents a C1-4 n-alkylene group wherein each carbon is optionally substituted by a C1-6 alkyl group; D represents CO, SO2, NH-CO or CH2CO; T represents hydrogen, alkyl, alkenyl or cycloalkyl; Z represents a bond, CH2, (CH2)2 or X-CH2-CH2 wherein X represents O or S; R1, R2 and R3 each independently represents H, alkyl, OH or alkoxy or, if attached to adjacent carbon atoms, any two of R1, R2 and R3 together with the carbon atoms to which they are attached may form a fused heterocyclic ring of five to six atoms wherein one, two or three of the said atoms are oxygen or nitrogen; R4 represents alkylsulphonamido, alkylamido or imidazo; and Ar represents substituted or unsubstituted aryl, wherein the optional substituents are the above defined R1, R2 and R3; a composition containing such a compound, a process for the preparation of such a compound and the use of such a compound in medicine.