首页>
外国专利>
IMMUNE REAGENTS REACTIVELY WITH A PRESERVED EPITOPE OF THE HUMAN IMMUNE DEFICIENCY VIRUS I (HIV- I) GP120 AND METHOD FOR USE THEREOF.
IMMUNE REAGENTS REACTIVELY WITH A PRESERVED EPITOPE OF THE HUMAN IMMUNE DEFICIENCY VIRUS I (HIV- I) GP120 AND METHOD FOR USE THEREOF.
展开▼
机译:用保留的人免疫缺陷病毒I(HIV-1)GP120抗原表位主动免疫,并使用其。
展开▼
页面导航
摘要
著录项
相似文献
摘要
The invention features immunoreagents which neutralize the Human Immunodeficiency Virus Type 1 (HIV-1) by binding to a novel conserved epitope of the HIV-1 gp120. These immunoreagents exhibit a broad neutralizing effect upon HIV attachment to host cells, and are therefore useful in the detection, prevention, amelioration and treatment of HIV disease, primarily AIDS (Acquired Immunodeficiency Syndrome) and ARC (AIDS Related Complex). More particularly, the invention relates to novel human monoclonal antibodies selectively reactive to a conserved conformation dependent determinant of the HIV-1 gp120, derivatives thereof, cell lines that produce these antibodies, and the use of the monoclonal antibodies and their derivatives for the detection, prevention, amelioration and treatment of HIV related disease. IMAGE
展开▼