ORAL OSMOTIC DEVICE FOR THE SUPPLY OF NICOTINE.

摘要

AN OSMOTIC DEVICE (10) IS DESCRIBED FOR THE CONTROLLED SYSTEMIC DISTRIBUTION OF NICOTINE THROUGH A MEMBRANE OF THE ORAL MUCOSA OF A HUMAN PATIENT. THE DEVICE (10) HAS A SIZE AND A SHAPE THAT ADAPTS IT TO BE COMFORTABLY RETAINED IN THE MOUTH DURING LONG PERIODS OF TIME. DEVICE (10) INCLUDES A SEMIPERMEABLE WALL (12) SURROUNDING A COMPARTMENT (13) CONTAINING A NICOTINE SALT (14) AND OPTIONALLY AN ALKALINE SALT THAT CAN REACT WITH THE NICOTINE SALT IN THE PRESENCE OF WATER TO FORM A BASE OF NICOTINE. THE NICOTINE BASE IS DISTRIBUTED FROM THE COMPARTMENT (13) THROUGH A DUCT (17) OF THE WALL (12). THE NICOTINE SALT SHOWS GOOD STABILITY AND A LIFETIME WHILE THE NICOTINE BASE SHOWS EXCELLENT ABSORPTION THROUGH THE MEMBRANES OF THE ORAL MUCOSAS.