首页> 外国专利> Use of 4-amino-1-(2-pyridyl)piperidines for the preparation of a medicament for the treatment and prophylaxis of conditions deriving from disorders of the serotoninergic systems mediated by 5-HT3 receptors

Use of 4-amino-1-(2-pyridyl)piperidines for the preparation of a medicament for the treatment and prophylaxis of conditions deriving from disorders of the serotoninergic systems mediated by 5-HT3 receptors

机译:4-氨基-1-(2-吡啶基)哌啶在制备药物中的用途,该药物用于治疗和预防由5-HT3受体介导的5-羟色胺能系统疾病引起的疾病

摘要

The subject of the present invention is the use of 4-amino-1-(2-pyridyl)piperidines of general formula (I') IMAGE in which R' represents hydrogen, a halogen atom, a methyl, trifluoromethyl, (C1-C3)alkoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio, trifluoromethylthio or phenoxy group which is optionally substituted by a halogen, a (C1-C3)alkyl, (C1-C3)alkoxy, (C1-C3)alkylthio, trifluoromethyl or cyano group, or one of its pharmaceutically acceptable salts, for the preparation of a medicinal product for the treatment and prophylaxis of conditions arising from a dysfunction of the serotoninergic systems in which a serotoninergic action, selectively mediated by 5-HT3 receptors, is required.
机译:本发明的主题是通式(I')的4氨基-1-(2-吡啶基)哌啶的使用,其中R'代表氢,卤素原子,甲基,三氟甲基,(C1 -C3)烷氧基,三氟甲氧基,2,2,2-三氟乙氧基,甲硫基,三氟甲硫基或苯氧基,其任选地被卤素,(C1-C3)烷基,(C1-C3)烷氧基,(C1-C3)烷硫基取代,三氟甲基或氰基,或其药学上可接受的盐之一,用于制备药物,用于治疗和预防由5-羟色胺能系统功能障碍引起的病症,其中5-羟色胺能受体由5-HT3受体选择性介导,是必须的。

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