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ANALOGS OF CYTOCHALASIN B AS RADIOPHARMACEUTICALS FOR NUCLEAR IMAGING OF TRANS-MEMBRANE GLUCOSE TRANSPORT
ANALOGS OF CYTOCHALASIN B AS RADIOPHARMACEUTICALS FOR NUCLEAR IMAGING OF TRANS-MEMBRANE GLUCOSE TRANSPORT
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机译:细胞松弛素B的类似物作为放射性药物的跨膜葡萄糖转运核成像
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摘要
Analogs of cytochalasin B are used as radiopharmaceuticals to provide an image for the nuclear imaging of glucose transport across cell membranes. Like cytochalasin B, the analogs bind specifically to glucose transport protein, and in doing so, serve as markers indicating the amount of glucose transport protein present on the surfaces of cells. The analogs differ from cytochalasin B by the inclusion of a radionuclide in the region of the terminal phenyl group on cytochalasin B, where the radionuclide does not interfere with the binding specificity of the analog. Disclosed herein are such analogs as well as analogs with which radionuclides readily accept at the desired location on the structure, either by conjugation or substitution.
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