Chalcone- and cinnamate-bearing polyphosphazenes, and methods for their preparation, are disclosed. The polyphosphazene derivatives can be prepared by derivatizing polydichlorophosphazene with one or more chalcone or cinnamate groups, or by derivatizing a chlorocyclotriphosphazene with one or more chalcone or cinnamate groups and polymerizing the chalcone- or cinnamate-bearing cyclotriphosphazene. The double bond in the chalcone and cinnamate groups can be crosslinked. The crosslinking can be initiated either thermally or photochemically. The polyphosphazenes can also contain ionically crosslinkable groups. Microparticles can be prepared by ionically and photochemically crosslinking the polyphosphazenes. These microparticles can encapsulate biologically active materials and imaging contrast agents, and can be functionalized with polyethylene glycol and targetting molecules.
展开▼