A compound of 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl and catalytic complexes thereof

摘要

A novel derivative of "BINAP" is the compound 2,2′-­bis[di-(m-tolyl)phosphino]-1,18-binapththyl represented by the formula:;The compound is synthesized by preparing (a) from di-m-tolyl phosphinic acid, di-(m-tolyl phosphonyl chlo­ride); and (b) a Grignard reagent by reacting 2,2′-dibromo-­1,1′-binaphthyl with Mg, and reacting the products of (a) and (b) to form a racemate of (I), which can be optically resolved into (+)- and (-)- isomers.;The compound is reacted with a compound of a transition metal (Ru, Rh, Pa), e.g., Ru Cl₂ (p-cymene), to make a complex useful in asymmetric hydrogenation of a β-keto ester to give products of high optical purity in high yield.