COUPLING AGENTS AND STERICALLY HINDERED DISULFIDE LINKED CONJUGATES PREPARED THEREFROM

摘要

the present invention relates to a coupling agent hu00e9tu00e9robifonctionnels intended to produce a wide range of molecular conjugates. these agents contain a thiol with steric hindrance, bound via a spacer arm to a second group which reacts with nucleophiles such as amines, primary and secondary or reactive thiols in biological and organic materials.the coupling agents are used to produce a combined with steric hindrance of binding.