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DIAGNOSIS AND TREATMENT OF BACTERIAL DYSENTERY.

机译:细菌性痢疾的诊断和治疗。

摘要

There is provided the use of an agent in the preparation of a medicament for the prevention or treatment of an enteric infection mediated by an SLT, wherein said agent is a pharmaceutically acceptable solid inert affinity support capable of being eliminated from the gastrointestinal tract, which support has an affinity ligand covalently attached thereto through a spacer arm, wherein said ligand is characterized as an oligosaccharide containing the disaccharide subunit alpha Gal(1-4) beta Gal which binds the SLT; with the proviso that the disaccharide is not part of a alpha Gal(1-4) beta Gal(1-4) beta GlcNAc trisaccharide or a alpha Gal(1-4) beta Gal(1-4) beta Glc trisaccharide.
机译:提供了该试剂在制备用于预防或治疗由SLT介导的肠感染的药物中的用途,其中所述试剂是能够从胃肠道中消除的药学上可接受的固体惰性亲和支持物,该支持物具有通过间隔臂共价附于其上的亲和配体,其中所述配体的特征在于包含与SLT结合的二糖亚基αGal(1-4)βGal的寡糖;前提是该二糖不属于αGal(1-4)βGal(1-4)βGlcNAc三糖或alpha Gal(1-4)βGal(1-4)βGlc三糖的一部分。

著录项

  • 公开/公告号EP0610356A4

    专利类型

  • 公开/公告日1995-03-29

    原文格式PDF

  • 申请/专利权人 CHEMBIOMED LTD;

    申请/专利号EP19920922817

  • 发明设计人 ARMSTRONG GLEN D;RATCLIFFE R MURRAY;

    申请日1992-10-19

  • 分类号C07K1/14;C07K17/10;C07K3/20;C07H3/06;C07H7/00;C07H15/04;

  • 国家 EP

  • 入库时间 2022-08-22 04:13:23

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