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A strain of saccharomyces cerevisiae expressing the gene encoding potassium transporter mink
A strain of saccharomyces cerevisiae expressing the gene encoding potassium transporter mink
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机译:表达酿酒酵母钾转运蛋白基因的酿酒酵母菌株
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摘要
A modified Saccharomyces cerevisiae cell, wherein the cell expresses minK but does not express TRK1 and TRK2. Also disclosed is a process for detecting modulators of minK, which comprises (a) treating such modified Saccharomyces cerevisiae cells with a test compound, (b) assessing growth in the presence of a test compound and (c) determining an increase or decrease in potassium uptake into the Saccharomyces cerevisiae cells. MinK inhibitors are useful anti-arrhythmic or antifibrillatory agents; activators, anti-ischemic agents.
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