PREPARATION AND USE OF NOVEL CYCLODEXTRIN-BASED DISPERSIBLE NANOVESICULAR COLLOIDAL SYSTEMS IN THE FORM OF NANOCAPSULES

摘要

A nanovesicular system prepared by (1) preparing a liquid phase essentially consisting of a solution of cyclodextrin modified by acyl groups, and an oil in an organic solvent or solvent mixture; (2) preparing a second liquid phase essentially consisting of water or an aqueous mixture optionally containing one or more surfactants, one of said phases (1) and (2) optionally having an active molecule added thereto; and (3) gently stirring one of the liquid phases resulting from (1) or (2) into the other in order to obtain, almost instantaneously, a colloidal solution of modified cyclodextrin nanocapsules containing oil and optionally said active molecule. If required, all or part of the solvent or solvent mixture and all or part of the water or aqueous mixture may be removed. Said system may be used as a carrier for pharmaceuticals, cosmetics, chemicals, etc.