Peptide derivatives of bactenecin endowed with antibacterial activity

摘要

A peptide of formula        Arg-Z₁-Pro-Z₂-Arg-Pro-Z₃   (I)whereinZ₁is Arg-Ile-Arg or Phe-Arg-Pro,Z₂is Arg-Pro-Pro-Arg-Leu-Pro or Ile-Arg-Arg-Pro-Pro-Ile,Z₃is Arg-Pro-Arg-Pro-Leu, Pro-Phe-Tyr-Pro-Pro-Phe-Arg-Pro, Arg-Pro-Arg-Pro-Leu-Pro-Phe-Pro-Arg-Pro, Pro-Phe-Tyr-Pro-Pro-Phe-Arg-Pro-Pro-Ile-Arg-Pro or Arg-Pro-Arg-Pro-Leu-Pro-Phe-Pro-Arg-Pro-Gly-Pro-Arg-Pro-Ile-Pro-Arg-Pro-Leu-Pro-Phe-Pro. Peptides are fragments and/or derivatives of naturally occurring bactenecins. They are endowed with antibacterial activity.