Human quinine protease inhibitor mutant (A HUMAN KUNITZ-TYPE PROTEASE INHIBITOR VARIANT)

摘要

The present invention relates to the following amino acid sequence (I) as a Kunitz-type protease inhibitor domain III variant of a tissue factor pathway inhibitor (TEPI);X^OneSer Trp Cys Leu Thr Pro Ala Asp X²Gly X³Cys X⁴X⁵X⁶X⁷X⁶X⁹;Phe Tyr Tyr Asn Ser Val Ile Gly Lys Cys Arg Pro Phe X¹⁰Tyr X¹¹;Gly Cys X¹²X¹³X¹⁴Glu Asn Asn Phe X¹⁵Ser Lys Gln Cys Leu Arg;Ala Cys Lys Lys X¹⁶(I);, Wherein X^OneRepresents 1 to 5 naturally occurring amino acid residues except for H or Cys, X²-X¹⁵Each independently represent a naturally occurring amino acid residue, X¹⁶Represents one to five naturally occurring amino acid residues except for OH or Cys, provided that the amino acid residue X^One-X¹⁶At least one of which is different from the corresponding amino acid residue of the native sequence.