N, N'-disubstituted guanidines and methods of using them as stimulating amino acid antagonists (N, N'-DISUBSTITUTED GUIDINES AND THEIR USE AS EXIT STATUS AMINO ACID ANTAGONISTS)

摘要

The present invention relates to N, N'-disubstituted guanidines with high binding affinity to phenylcyclyidine (PCP) receptors. These N, N'-disubstituted guanidines act as non-competitive inhibitors of the glutamate-induced response formed through the NMDA receptor, acting as a blocking agent for the ion channel of the NMDA receptor-ion channel complex. These compounds thus exhibit neuroprotective properties and are useful in the treatment of hypoxia hypoglycemia, brain or spinal anemia, neurological damage in the brain or spinal cord trauma, and also in the treatment of epilepsy, Alzheimer ' s disease, , Koscakov's disease, and other neurodegenerative diseases.