3-Phenylureido-azepin-2-one and 3-PHENYLUREIDO-AZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS, which are useful as cholecystokinin antagonists,

摘要

The present invention relates to novel substituted hexahydroazepinones and tetrahydrobenzazepinones of the general formulas (I) and (II), and novel intermediates used in the synthesis of these compounds:;In the above formula, Y^OneAnd Y²Is independently phenyl, thienyl, pyridyl, furyl, pyrimidyl, (C₃-C₈) Straight or branched chain alkyl and (C₃-C₈Cycloalkyl, wherein said phenyl, thienyl, pyridyl, furyl and pyrimidyl are optionally substituted with halo (such as chloro, fluoro, bromo or iodo), (C_One-C₆) Alkyl, (C_One-C₆) Alkoxy, nitro, amino and trifluoromethyl, said cycloalkyl being optionally substituted with one or two substituents independently selected from the group consisting of (C_One-C₆) Alkyl; /RTI Z^OneAnd Z²Is independently halo, (C_One-C₆) Alkyl, (C_One-C₆) Thioalkyl, (C_One-C₆) Alkoxy, trifluoromethyl, (C_One-C₆) Carboalkoxy, amino, and nitro; R^OneIs phenyl, CO²R², S0²NR³R⁶Or CONR⁴R⁵, Wherein said phenyl is optionally substituted with halo, (C_One-C₆) Alkyl, (C_One-C₆) Optionally substituted with one or two substituents independently selected from the group consisting of alkoxy, nitro, amino and trifluoromethyl, R², R³, R⁴, R⁵And R⁶Is independently hydrogen, (C₃-C₁₂) Alkyl and a condensed saturated carbocyclic system containing two or three rings.;These compounds are useful for the treatment and prevention of gastrointestinal diseases, pain and anxiety disorders.