METHOD OF PREPARATION PREPARING FOR DIRECTED DELIVERY OF ANTITUMOR DRUGS IN MALIGNANT CELL

摘要

FIELD: medicine. SUBSTANCE: human abortive material is milled without cell destruction. Prepared mass is extracted with butyl alcohol. Extract is dialyzed against 0.05M NaCl solution, concentrated up to the alpha-fetoprotein content 100 mcg/ml and sterilized. Then preparation is subjected for conjugation with antitumor drug - doxorubicin with ligand - estrone taken at the equimolar ratio. Then preincubation of treated biological material with conjugate is carried out. EFFECT: improved method of preparing. 5 cl