METHOD OF SYNTHESIS OF 6-FLUORO-1,2-BENZISOTHIAZOLE, ORTHO-SUBSTITUTED PHENACYL-DERIVATIVE, AND A METHOD OF ITS SYNTHESIS

摘要

FIELD: organic chemistry. SUBSTANCE: product - 6-fluoro-1,2- benzoisothiazoles of the formula (I) where R - hydrogen, lower alkyl or a group of the formula (II) or (III) where R₁-CHO or -CN. Reagent 1: compound of the formula (IV) where R as indicated above; R₃ - benzyl. Reagent 2: halogenating agent, preferably sulfuryl chloride. Reagents 1 and 2 after interaction form compound of the formula (V) which is subjected for interaction with ammonia, preferably at the room temperature. Compound of the formula (IV) is synthesized from the compound of the formula (VI) and benzylmercaptan in the medium of aprotonic organic solvent. Synthesized products were used as intermediate compounds for synthesis of pharmaceutically active substances. EFFECT: improved method of synthesis. 6 cl