METHOD OF PREPARING CRYSTALLINE 7-2-(2- AMINOTHIAZOLE-4-YL) -2(Z)-METHOXYIMINOACETAMIDO -3-(1- -METHYL -1-PYRROLIDINO) METHYL -CEPH-3- EM-4-CARBOXYLATE DIHYDROCHLORIDE MONO- OR DIHYDRATE FREE FROM ANTIISOMER AND ²-ISOMER

摘要

FIELD: organic chemistry. SUBSTANCE: product: acid-additive salt of 7-amino-3- [(1-methyl -1-pyrrolidino) methyl] -ceph -4-carboxylate of the formula (I) where HX^- HCl, HJ or sulfuric acid free from ²-isomer is subjected for interaction with 2-(2-a minothazole-4-yl) -2-methoxyiminoacetyl-chloride hydrochloride free from antiisomer in aqueous-organic solvent at pH 5.0-7.5 following by isolation of the end product from the reaction mixture in the form of crystalline mono- or dihydrate dihydrochloride. EFFECT: improved method of preparing. 2 cl, 4 dwg, 1 tbl