where . These compounds increase survival life span of animals as compared with known standard N-bis- (ethyleneimino)phosphonyl-N, -3-(2-chloro -1,1,2-trifluoroethyoxy) phenylurea and show decreased toxicity. Product 2: compounds of the formula (II) XC6H4-NH2, where X 4-S-C3F7, 3-O-CF2-CHF-GF3. Product 3: compounds of the formula (III) XC6H4-NH-C(O)-NH-P(O)-(Cl)2, where X as for compound of the formula (I). Reaction conditions for compounds of the formula (II): condensation of p-aminothiophenol with heptafluoropolypropyl iodide in liquid ammonia and UV-light following by ammonia removing, treatment with KOH and extraction with ether; perfluoropropylene bubbling through the aqueous solution of 3-acetylaminophenol and triethylamine at 90 C following by treatment with HCl at cooling and extraction with benzene. Reaction conditions for compounds of the formula (III) addition of amine solution of the formula (II) to isocyanatophosphoric acid dichloroanhydride in ether. Reaction conditions for compounds of the formula (I): aziridine treatment with compound of the formula (II) in the medium of CHCl3 in the presence of triethylamine at 4-6 C. Synthesized compounds were used for synthesis of medicinal agents. EFFECT: improved method of synthesis. 4 cl, 1 tbl"/>
N'-BIS- (ETHYLENEIMINO)PHOSPHONYL- N''- ARYLUREAS SHOWING ANTIBLASTIC ACTIVITY, N'-DICHLOROPHOSPHONYL -N''- ARYLUREAS FOR SYNTHESIS OF N'-BIS- (ETHYLENEIMINO)PHOSPHONYL -N''-ARYLUREAS AND FLUORO-CONTAINING ANILINES FOR SYNTHESIS OF N'- DICHLOROPHOSPHONYL -N''-ARYLUREAS
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N'-BIS- (ETHYLENEIMINO)PHOSPHONYL- N''- ARYLUREAS SHOWING ANTIBLASTIC ACTIVITY, N'-DICHLOROPHOSPHONYL -N''- ARYLUREAS FOR SYNTHESIS OF N'-BIS- (ETHYLENEIMINO)PHOSPHONYL -N''-ARYLUREAS AND FLUORO-CONTAINING ANILINES FOR SYNTHESIS OF N'- DICHLOROPHOSPHONYL -N''-ARYLUREAS
N'-BIS- (ETHYLENEIMINO)PHOSPHONYL- N''- ARYLUREAS SHOWING ANTIBLASTIC ACTIVITY, N'-DICHLOROPHOSPHONYL -N''- ARYLUREAS FOR SYNTHESIS OF N'-BIS- (ETHYLENEIMINO)PHOSPHONYL -N''-ARYLUREAS AND FLUORO-CONTAINING ANILINES FOR SYNTHESIS OF N'- DICHLOROPHOSPHONYL -N''-ARYLUREAS
FIELD: organic chemistry. SUBSTANCE: product 1: compound of the general formula (I) where . These compounds increase survival life span of animals as compared with known standard N-bis- (ethyleneimino)phosphonyl-N, -3-(2-chloro -1,1,2-trifluoroethyoxy) phenylurea and show decreased toxicity. Product 2: compounds of the formula (II) XC6H4-NH2, where X 4-S-C3F7, 3-O-CF2-CHF-GF3. Product 3: compounds of the formula (III) XC6H4-NH-C(O)-NH-P(O)-(Cl)2, where X as for compound of the formula (I). Reaction conditions for compounds of the formula (II): condensation of p-aminothiophenol with heptafluoropolypropyl iodide in liquid ammonia and UV-light following by ammonia removing, treatment with KOH and extraction with ether; perfluoropropylene bubbling through the aqueous solution of 3-acetylaminophenol and triethylamine at 90 C following by treatment with HCl at cooling and extraction with benzene. Reaction conditions for compounds of the formula (III) addition of amine solution of the formula (II) to isocyanatophosphoric acid dichloroanhydride in ether. Reaction conditions for compounds of the formula (I): aziridine treatment with compound of the formula (II) in the medium of CHCl3 in the presence of triethylamine at 4-6 C. Synthesized compounds were used for synthesis of medicinal agents. EFFECT: improved method of synthesis. 4 cl, 1 tbl
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机译：领域：有机化学。物质：产品1：通式（I）的化合物<图像文件=“ 00000003.GIF” he =“ 8” id =“ imag0.3” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 67” / >，其中。与已知的标准N-双-（亚乙基亚氨基）膦酰基-N，-3-（2-氯-1,1,2-三氟乙氧基）苯基脲相比，这些化合物可延长动物的生存期，并降低毒性。产品2：具有化学式（II）的化合物XC 6 H 4 -NH 2 ，其中X 4-SC 3 F 7 ，3-O-CF 2 -CHF-GF 3 。产物3：式（III）的化合物XC 6 H 4 -NH-C（O）-NH-P（O）-（Cl） 2 ，其中X表示式（I）的化合物。式（II）化合物的反应条件：对氨基硫酚与七氟聚碘甲烷在液氨中的缩合反应，然后用紫外线除去氨，用KOH处理并用乙醚萃取。全氟丙烯在90℃下鼓泡通入3-乙酰氨基苯酚和三乙胺的水溶液中，随后在冷却下用HCl处理并用苯萃取。式（III）化合物的反应条件：将式（II）的胺溶液加到醚中的异氰酸根合磷酸二氯酐中。式（I）化合物的反应条件：在三乙胺存在下于4-6 C在CHCl 3 介质中用式（II）化合物氮丙啶处理。将合成的化合物用于合成药物。效果：改进的合成方法。 4厘升，1汤匙
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