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Tri- and tetrasubstituted oxetanes and tetrahydrofurans and their intermediates.
Tri- and tetrasubstituted oxetanes and tetrahydrofurans and their intermediates.
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机译:三和四取代的氧杂环丁烷和四氢呋喃及其中间体。
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摘要
This invention relates to tri- and tetra-substituted-oxetanes of the formula, CHEM e.g. (+/-)-cis- and (+/-)-trans-2-[(4-(4-isopropylpiperazin-1-yl)phenoxy)methyl]-4-(2,4-di halop henyl)-4-[1H-1,2,4-triazol-1-yl)methyl]oxetane and tri- and tetra- substituted-tetrahydrofurans, e.g. (+/-)-cis- and (+/-)-trans-1-[4-[[2-(2,4-dihalophenyl)tetrahydro-2-[(1H-azol-1-yl)m ethyl]-5-furanyl]methoxy]phenyl]-4-yl-1-substituted piperazine-3-one and related derivatives which exhibit antifungal and antiallergy activities, pharmaceutical composition thereof, methods of their use in treating or preventing susceptible fungal infections and allergic reactions in a host including warm-blooded animals such as humans.
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