BLACK-SPECIFIC IMMUNOCONJUGATE.

摘要

Immunoconjugates are described comprising a platelet-specific antibody or antibody fragment coupled to a thrombolytic agent. The antibody, or fragment thereof, is, preferably, specific for the glycoprotein IIb/IIIa receptor in its complexed form. These antibodies block ligand binding to the receptor, thereby preventing platelet aggregation which has been implicated in the formation of thrombi. The thrombolytic agent, either in natural or recombinant form, promotes fibrinolysis in the thrombus. These immunoconjugates are useful in anti-thrombotic therapy.