a lid for the inclusion of columns for double-sided and unilateral simulation of thrombosentstehung in partially closed blood vessel.

摘要

PCT No. PCT/NO92/00117 Sec. 371 Date Apr. 18, 1994 Sec. 102(e) Date Apr. 18, 1994 PCT Filed Jun. 29, 1992 PCT Pub. No. WO93/00989 PCT Pub. Date Jan. 21, 1993The invention relates to a perfusion chamber 1, a mixing device 21, and a cover slip holder 6 for use together with the perfusion chamber 1. The bottom of the cover slip holder 6 is provided with cross-located grooves 11, 12, 13-1 for installing cover slips 14, 15, 16-1, and in which the cover slips 14, 15, 16-1 are positioned in comparison to each other in such a way that the cross-sectional area of the flow channel 4 is constricted unilaterally, for simulation of thrombogenesis in human blood vessels with stenosis. The bottom of the perfusion chamber 1, in the measure chamber 7, can also have an elevation into the flow channel 4 in the measure chamber 7 which together with the recessed cover slip holder bottom produces a bilateral constriction of the cross-sectional area of the measure chamber 7. A mixing device 21 is connected to the system upstream of the perfusion chamber 1 and produces homogeneous mixing of solutions added to the blood flow. The use of the perfusion chamber 1, the cover slip holder 6 and the mixing device 21 is described.