Hybrid protein complex, their process of preparation and their applications as diagnostic agent, as an agent or as a referred other reactant used in medical imaging.

摘要

Hybrid protein complexes comprising the light chains and the variable regions and some of the constant regions of the immunoglobulin heavy chains and another protein homo - or heterodimer, their preparation process, as well as their applications as diagnostic agent, as a therapeutic agent or as a reagent which can be used in medical imaging. & br / said hybrid protein of the type comprising an immunoglobulin fragment, fused with another protein p, is constituted by a sequence of hybrid complex comprising: & br / . a base unit u is constituted by: & br / - two different peptide chains su1 and su2, su1 comprising the variable regions and constant of a light chain of an immunoglobulin and su2 comprising at least the variable regions and the ch1 region of a heavy chain of an immunoglobulin, which peptide chains su1 and su2 are interconnected by at least a disulfide bridge and & br / - at least one functional fragment of one of the two under - units of a dimeric protein p, fused by its end n - terminal to one of the peptide chains su1 or su2 = br / which base unit u is associated with a base unit u ', identical or different from the unit u, by means of - units of the protein p or a fragment of those -.