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Regioselective synthesis of 1,5-diaryl pyrazole anti-inflammatory agents
Regioselective synthesis of 1,5-diaryl pyrazole anti-inflammatory agents
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机译:区域选择性合成1,5-二芳基吡唑类抗炎药
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摘要
The invention provides a process for preparing 1,5-diaryl pyrazole anti-inflammatory agents. A 6-aryl-4,6-dioxohexanoic acid is treated with acetic anhydride or acetyl chloride to produce an enol lactone, which is added to methylhydroxylamine to generate the dione hydroxamic acid. This dione hydroxamic acid is then treated with 4- methoxyphenylhydrazine hydrochloride to yield the 1,5-diaryl pyrazole. Novel intermediate compounds in the synthetic pathway are also disclosed.
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