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Method of increasing intracellular accumulation of hydrophilic anionic agents using gemfibrizol
Method of increasing intracellular accumulation of hydrophilic anionic agents using gemfibrizol
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机译:使用吉非贝唑增加亲水性阴离子剂在细胞内积累的方法
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摘要
This invention provides an improved therapeutic method which comprises administering to a mammal a therapeutic agent and 5-(2,5- dimethylphenoxy)- 2,2-dimethyl-pentanoic acid, or a structural analog thereof, in an amount effective to improve the efficacy of the therapeutic agent. Also provided by this invention is an improved therapeutic method which comprises administering to a mammal a therapeutic agent and 5-(2,5-dimethylphenoxy)- 2,2-dimethyl-pentanoic acid, or a structural analog thereof, in an amount effective to improve the efficacy of the therapeutic agent. Further provided by this invention is a method of treating an intracellular bacterial infection which comprises contacting the infected cell with an effective amount of a therapeutic agent and with an effective amount of 5- (2,5-dimethylphenoxy) -2,2-dimethyl-pentanoic acid, or a structural analog therof, effective to treat an intracellular bacterial infection. A pharmaceutical composition is further provided by this invention wherein the composition comprises a therapeutic agent and 5-(2,5-dimethylphenoxy)- 2,2-dimethylpentanoic acid, or a structural analog thereof, and a pharmaceutically acceptable carrier.
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