首页>
外国专利>
Enhancement of transdermal delivery with ultrasound and chemical enhancers
Enhancement of transdermal delivery with ultrasound and chemical enhancers
展开▼
机译:用超声波和化学增强剂增强透皮递送
展开▼
页面导航
摘要
著录项
相似文献
摘要
A method of enhancing the permeability of the skin or mucosa to a biologically active permeant or drug is described utilizing ultrasound or ultrasound plus a chemical enhancer. If desired the ultrasound may be modulated by means of frequency modulation, amplitude modulation, phase modulation and/or combinations thereof. A frequency modulation from high to low develops a local pressure gradient directed into the body, thus permitting permeant to traverse the skin or mucosa. The enhanced delivery is preferably accomplished using a chemical enhancer, applying ultrasound optionally at a modulated frequency, amplitude, phase, or combinations thereof that further induces a local pressure gradient into the body. The method is also useful as a means for application of a tattoo by noninvasively delivering a pigment through the skin surface.
展开▼