Pre-adaptation of xenograft organ graft, supply method of the protein by the transmembrane transition for the purpose of other

摘要

GPI-linked proteins are transferred, especially (in vivo), from vertebrate carrier cells to cells of a target vertebrate tissue. For example, for purposes of xenogeneic transplantation, cells bearing complement inhibition factor(s) specific for the recipient species, e.g., genetically engineered, red blood cells, are incubated with transplantable cells of a second, discordant donor species until transfer of the factor(s) occurs, The transfer may occur in vivo or in vitro, and the factor-bearing cells may be normal cells of the recipient species, or genetically engineered cells of the donor species which express a gene encoding a complement inhibition factor(s) of the recipient species. The method is particularly useful in modifying pig organs for xenotransplantation into humans.