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METHOD OF DIAGNOZING SENSITIVITY FOR CANCER,PRECANCER OR OTHER TYPE OF DISEASE BY ANALYSIS OF IRF-1 SPECIFIC RNA IN BIOPSY SAMPLE
METHOD OF DIAGNOZING SENSITIVITY FOR CANCER,PRECANCER OR OTHER TYPE OF DISEASE BY ANALYSIS OF IRF-1 SPECIFIC RNA IN BIOPSY SAMPLE
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机译:通过活检样品中IRF-1特异性RNA分析诊断癌症,癌症或其他类型疾病的敏感性的方法
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摘要
The present invention relates to a method of diagnosing cancer, precancerous state, and susceptibility to other forms of diseases, by use of a molecular marker, interferon-regulatory factor-1 (IRF-1). The method is characterized in that IRF-1-specific RNA is analysed in a sample obtained from blood or other biopsy material, preferably by reverse transcription/polymerase chain reaction. The invention is based on the unexpected finding that a novel mechanism of inactivation of the tumor suppressor gene IRF-1 plays a crucial role e.g. in hematopoietic malignancies. An unusual exon skipping leads to RNA molecules which lack exon 2 or exons 2 and 3. The relative amounts of full-length RNA and shortened RNA molecules are significantly different in samples obtained from tumor patients as compared to healthy donors. IMAGE
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