首页> 外国专利> HYPOMYCIN, STRAIN CAPABLE OF PRODUCING HYPOMYCIN, PRODUCTION OF HYPOMYCIN AND REGULATOR FOR ACAT ACTIVITY

HYPOMYCIN, STRAIN CAPABLE OF PRODUCING HYPOMYCIN, PRODUCTION OF HYPOMYCIN AND REGULATOR FOR ACAT ACTIVITY

机译：hypomycin，生产hypomycin的应变能力，hypomycin的生产和ACAT活性调节剂

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摘要

PURPOSE: To obtain a new hypomycin, capable of lowering the level of choles terol in blood and suppressing arteriosclerosis and having regulating actions on the activities of acyl-coenzyme A-cholesterol acyltransferases (ACAT). ;CONSTITUTION: The hypomycin of the formula. This hypomycin is obtained by culturing Hypomyces sp. C409 (FERM P-14374) which is a microorganism belonging to the genus Hypomyces at 24-30C and about the neutral pH under preferably aerobic conditions, accumulating the hypomycin in the resultant cultured product, separating the cultured product into a culture filtrate and a microbial cell by centrifugation, etc., and respectively collecting the hypomycin. The obtained hypomycin has the following physico-chemical properties: molecular formula: C₁₉H₁₉N₁O₃; molecular weight: 309; specific rotatory power []²⁰D= 84.60 (CHCl₃, c=0.5); solubility; soluble in MeOH, Et0H, acetonitrile, EtOAc, CHCl₃ and benzene and insoluble in water; neutral; white powder, etc.;COPYRIGHT: (C)1996,JPO

机译：目的：获得一种新的次霉素，能够降低血液中的胆甾醇水平并抑制动脉硬化，并对酰基辅酶A-胆固醇酰基转移酶（ACAT）的活性具有调节作用。 ;组成：该配方的次霉素。该次霉素通过培养Hypomyces sp。获得。 C409（FERM P-14374）是在24-30℃和优选在需氧条件下在中性pH附近属于hypomyces属的微生物，在所得到的培养产物中积聚次霉素，将培养产物分离为培养滤液和微生物。通过离心等方法收集细胞，并分别收集次霉素。所得的次霉素具有以下物理化学性质：分子式：C _{19 H _{19 N _{1 O _{3 ;分子量：309;比旋光度[] ^{20 D = 84.60（CHCl _{3 ，c = 0.5）;溶解度溶于MeOH，EtOAc，乙腈，EtOAc，CHCl _{3 和苯，不溶于水;中性;白色粉末等;版权：（C）1996，日本特许厅}}}}}}}

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公开/公告号JPH0841064A

专利类型
公开/公告日1996-02-13

原文格式PDF
申请/专利权人 YAKULT HONSHA CO LTD;
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申请/专利号JP19940181334
发明设计人 SAWADA HARUJI;CHATANI TAKAKO;TEZUKA KENICHI;WATANABE TSUNEICHI;YOKOKURA TERUO;
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申请日1994-08-02
分类号C07D477/00;A61K31/40;C12N1/14;C12P17/18;
国家 JP
入库时间 2022-08-22 03:59:06

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