RACEMIC ALIPHATIC HETEROCYCLIC CARBOXYLIC ACID ESTER, AND PRODUCTION OF RACEMIC ALIPHATIC HETEROCYCLIC CARBOXYLIC ACID

摘要

PURPOSE: To obtain the subject compound in a short time and in a high yield under mild conditions by racemizing an optically active aliphatic heterocyclic carboxylic acid ester in the coexistence of as a base. ;CONSTITUTION: An optically active aliphatic heterocyclic carboxylic acid ester of the formula (R is 1-5C alkyl; n is 1,2) (e.g. optically active tetrahydrofuran-2- carboxylic acid ester) is racemized in the coexistence of a base (preferably an alkali metal alkoxide, alkali metal hydride, alkali metal amide) to obtain the objective compound. The catalyst is preferably used in an amount of 0.01-35mol% based on the compound of formula. The racemization reaction is preferably performed at 0-65°C under an anhydrous condition. The reaction time is usually 0.1-30hr. A racemic aliphatic heterocyclic carboxylic acid is obtained by hydrolyzing the objective compound.;COPYRIGHT: (C)1996,JPO