PREDICTION OF BONE DENSITY, BONE METABOLIC TURNOVER AND/ OR BONE DISEASE-SUFFERING RISK

摘要

PURPOSE: To predict a bone density, bone metabolic turnover and a bone disease- suffering risk for preventing osteoporosis, etc., by measuring the polymorphism of a vitamin D-bound protein and subsequently connecting the measured result to the degree of the bone density, the degree of the bone metabolic turnover and the bone disease. ;CONSTITUTION: The polymorphism of six kinds of genes formed from the combination of GC¹S, GC¹F and GC², etc., is measured as the polymorphism of a vitamin D-bound protein or its gene. The measured result is connected to the degree of bone density, the degree of bone metabolic turnover and/or a bone disease to classify a gene type GC2-2 and a gene type GC2-1S as a low bone density type, high bone metabolic turnover type or bone disease-suffering risk type and as a non-low bone density type, low bone metabolic turnover type or bone disease-suffering risk type, respectively. Thus, it is predicted that the bone density and the risk of suffering the bone disease such as osteoporosis will be lowered and enhanced, respectively, in the future in the high bone metabolic turnover group. The prediction is thereby useful for paying attention to meals or nutrients and life habits to prevent the lowering of the bone density and avoid the suffering by a bone disease such as osteoporosis in the future.;COPYRIGHT: (C)1996,JPO