EVALUATION OF AGGLOMERATION CHARACTERISTICS OF CARRIER PARTICLES FOR IMMUNOLOGICAL AGGLOMERATION REACTION

摘要

PURPOSE: To evaluate the agglomeration characteristics of carrier particles having a high sedimentation speed by premixing standard carrier particles and an agglomerating agent with water in various ratios to disperse them and together using the electric conductivities of respective mixed solns. and agglomeration decision by a microtiter method to calculate the lowest electric conductivity generating agglomeration. ;CONSTITUTION: As a standard carrier, org. and inorg. composite particles for microtitration are used to be well washed with pure water. Next, an agglomerating agent aq. soln. is prepared as an agglomerating agent by dissolving sodium chloride in pure water, for example, in an amt. of 20wt.% and mixed with the standard carrier particle dispersion in various ratios under stirring and the electric conductivities of the respective mixed dispersions are measured. The respective mixed dispersions after the completion of measurement are transferred to microwells to be allowed to stand and the presence of the agglomeration images of the bottoms of the microwells is observed and the lowest electric conductivity (agglomeration electric conductivity) generating agglomeration is calculated to be compared with the electric conductivity of a carrier to be evaluated to evaluate whether agglomeration is good.;COPYRIGHT: (C)1996,JPO