首页> 外国专利> Compounds containing oral Pharmaceutical Excipients mucoadhesivos Soluble in water and a method for the treatment of Cough and the discomfort caused by the ringofaringitis - and for theTreatment of gastrointestinal disorders

Compounds containing oral Pharmaceutical Excipients mucoadhesivos Soluble in water and a method for the treatment of Cough and the discomfort caused by the ringofaringitis - and for theTreatment of gastrointestinal disorders

机译:含有可溶于水的口服药物赋形剂的化合物,可溶于水以及治疗咳嗽和由环指炎引起的不适的方法以及用于治疗胃肠道疾病的方法

摘要

A Slurry containing mucoadhesive oral Pharmaceutical excipient from near 0.05 you ta about 20% of a mucoadhesive Polymer Solu - ble in water where the composite have a fuer za (measured as adhesion Force, escaping from near 0).5 to 10 sec Near Newton, a viscosity of from about 1.0 to about 1.0 to about 10 N, An - cient of Thermal viscoelasticity from near 0.20 to about 30 dyn / cm2 and the Mechanical Impedance of about 0.15 to 0.6 degree between the frequency range of 1 to 10 Hz.A compound containing mucoadhesive oral Solid Pharmaceutical excipient from near 0.05 to near 20% of a water-soluble mucoadhesive Polymer selected from the group consisting of Poly (ethylene oxide), Poly (ethylene glycol), Poly (Vinyl alcohol); Poly (Vinyl pyrrolidine)Poly (acrylic acid), Poly (Hydroxy Ethyl methacrylate, hydroxypropyl Cellulose, hydroxyethyl Cellulose, hydroxyethyl Ethyl Cellulose, Ethyl hidroextil cellulo SA and Chitosan and mixtures of them.A method for the treatment of Cough in human or animal comprising administering a safe and effective amount of the compound of the invention.As to the Treatment or to reduce irritation.Pain or descomfort associated with laringofaringitis in human or animal comprising administering a safe and effective amount of the compound of the Invention and a methodFor the treatment of Upper Gastrointestinal Disorders in animals including hunmanos or Treason - a safe and effective amount of the com - position of which is this inventionOn.
机译:含粘膜粘附性口服药物赋形剂的浆液,在复合物中有fuer za(以粘附力计,从0附近逸出)。约5至10秒钟内,在水中粘膜粘附性聚合物可溶物的0.05%至约20%左右。在1至10 Hz的频率范围内,其粘度约为1.0至1.0 N(约1.0到1.0 N),热粘弹性系数约为0.20到约30 dyn / cm2,机械阻抗约为0.15到0.6度。一种含有粘膜粘附性口服固体药物赋形剂的化合物,该赋形剂为选自聚环氧乙烷,聚乙二醇,聚乙烯醇中的水溶性粘膜粘附性聚合物的0.05%至20%。聚(乙烯基吡咯烷)酯(丙烯酸),聚(甲基丙烯酸羟乙酯),羟丙基纤维素,羟乙基纤维素,羟乙基乙基纤维素,羟乙基硬脂纤维素SA和壳聚糖及其混合物。一种治疗人或动物咳嗽的方法,包括关于治疗或减少刺激性人或动物与唇肌炎相关的疼痛或不适包括给药安全和有效量的本发明化合物及治疗方法包括hunmanos或叛逆性动物在内的上消化道疾病的治疗-一种安全有效量的成分-本发明。

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