首页> 外国专利> POLYCOSANOL, A MIXTURE OF SUPERIOR PRIMARY ALIPHATIC AS PLATELET HYPERCLUMPING, ISCHEMIC ACCIDENTS, THROMBOSIS AND ALSO EFFECTIVE AGAINST CHEMICALLY INDUCED GASTRIC AND PROCEDURE FOR ITS PREPARATION FROM SUGAR CANE.ALCOHOLS FOR TREATING ATHEROSCLEROTIC COMPLICATIONS SUCH

POLYCOSANOL, A MIXTURE OF SUPERIOR PRIMARY ALIPHATIC AS PLATELET HYPERCLUMPING, ISCHEMIC ACCIDENTS, THROMBOSIS AND ALSO EFFECTIVE AGAINST CHEMICALLY INDUCED GASTRIC AND PROCEDURE FOR ITS PREPARATION FROM SUGAR CANE.ALCOHOLS FOR TREATING ATHEROSCLEROTIC COMPLICATIONS SUCH

机译:聚山梨醇,一种作为血小板超凝集的高级原始脂肪族化合物,具有缺血性发作,血栓形成,并且还可以有效地化学诱导从糖蔗中制得胃泌素,并且可以通过糖蔗糖制备醇的方法。

摘要

The current invention is related to the branches of chemistry and pharmacology, especially a mixture of high molecular weight primary alifatrol, which eventually expanded to 22 to 38 carbon atoms. In particular, the linear chain of 24 to 34 carbon atoms, especially 24, 26, 27, 28, 29, 30, 32 and 34 carbon atoms,It's policosanol This mixture shows the relative composition of each alcohol, which can be reproduced in large batches. In addition, each alcohol is mixed in a specific supply. This kind of mixed alcohol has specific pharmacological properties. It can be used as active ingredient in drug formulation, as antiplatelet, antithrombotic and anti hypoxia drugs. This mixture of alcohol is effective in addition to inhibiting gastric ulcer by different drugs and compounds, such as aspirin,Alcohol, methadone and competop C 4880 (Upjohn), etc. Considering the acute, subchronic and chronic toxicology of rodents and lizards, as well as the results of chronic studies in rodents, the toxicity is practically zero,No teratogenic effects were observed in dogs and monkeys, and even studies of mutations in vivo and in vitro have shown that the product has no mutagenic effect. No side effects were found on the subject matter of the invention. The basis of the propagation process is to use different alkaline and alkaline hydroxides to ceramic the wax of the same phase, and to use organic solvents for solid extraction, such as ketones with 3-8 carbon atoms, hydrocarbons with 6-9 carbon atoms, and alcohol with 1-5 carbon atoms, Halogens and talented aromatic compoundsHalogens, benzene and its derivatives and their mixtures may include cetaceans with 3-5 carbon atoms, halogens with 1-2 carbon atoms and alcohol with 1-3 carbon atoms.
机译:本发明涉及化学和药理学的分支,特别是高分子量伯阿里发特罗的混合物,其最终扩展到22至38个碳原子。尤其是24至34个碳原子的线性链,尤其是24、26、27、28、29、30、32和34个碳原子。它是policosanol这种混合物显示了每种醇的相对组成,可以大量复制批次。此外,每种酒精都按特定的供应量进行混合。这种混合酒精具有特定的药理特性。它可以用作药物制剂中的活性成分,用作抗血小板,抗血栓和抗缺氧药物。这种酒精混合物除了可以通过不同的药物和化合物(例如阿司匹林,酒精,美沙酮和competop C 4880(Upjohn)等)抑制胃溃疡外,也是有效的。考虑到啮齿动物和蜥蜴的急性,亚慢性和慢性毒理学作为对啮齿动物的长期研究结果,其毒性几乎为零,在狗和猴子中未观察到致畸作用,甚至在体内和体外进行的突变研究也表明该产品没有诱变作用。在本发明的主题上未发现副作用。繁殖过程的基础是使用不同的碱性和碱性氢氧化物来陶瓷同一相的蜡,并使用有机溶剂进行固相萃取,例如碳原子数为3-8的酮,碳原子数为6-9的烃,以及具有1-5个碳原子的醇,卤素和有才华的芳族化合物卤素,苯及其衍生物及其混合物可能包括具有3-5个碳原子的鲸蜡类动物,具有1-2个碳原子的卤素和具有1-3个碳原子的醇。

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