N-fosfonylmetoxyalkylderivater of pyrimidine bases and purine bases, methods for their preparation, and the pharmaceutical composition having antiviral activity containing such a derivative

摘要

This invention relates to new nucleotide analogues exhibiting antiviral activity which represent N-(2-phosphonylmethoxyethyl) and N-(3-hydroxy-2-phosphonylmethoxypropyl) derivatives of pyrimidine and purine bases and to methods for their preparation and to their use in pharmaceutical compositions. These compounds are easily accessible from heterocyclic bases and their N-(2-hydroxyethyl) or N-(2,3-dihydroxypropyl) derivatives. Some of the compounds according to this invention exhibit a marked antiviral activity or can be converted into such active compounds by chemical transformations.