4- and 6-Carbamates related to physostigmine, a process and intermediates for their preparation and their use as medicaments

摘要

The present invention relates to compounds of the formula I, CHEM where X is hydrogen, halogen or loweralkyl; and R1, R2 and R3 are each independently hydrogen, loweralkyl, cycloalkyl, arylloweralkyl or aryl, or alternatively the group -NR2R3 taken as a whole constitutes CHEM R4 being hydrogen or loweralkyl and a process for their preparation. The compounds of the invention show central cholinergic innervative properties for treating various memory dysfunctions and can, therefore, be used as medicaments.