NOVEL BENZOXAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS OF HIV RESERVE TRANSCRIPTASE INHIBITOR ACTIVITY CONTAINING THEM AND PROCESS FOR PREPARING 6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUORO-METHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE

摘要

Certain benzoxazinones of the formula: CHEM wherein: X is halo, X1 is trihalomethy, or pentahaloethyl; Z is O; are useful in the inhibition of HIV reverse transcriptase (including its resistant varieties), the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.