CHELATORS OF TYPE XN1S1X' BRAKED WITH TWOVALENT CALCOGENE ATOM FOR RADIOACTIVE ISOTOPES, THEIR METAL COMPLEXES AND THEIR DIAGNOSTIC AND THERPEUTICAL USES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESS FOR PRODUCING THEM

摘要

PCT No. PCT/DE94/00372 Sec. 371 Date Dec. 9, 1996 Sec. 102(e) Date Dec. 9, 1996 PCT Filed Mar. 29, 1994 PCT Pub. No. WO94/22493 PCT Pub. Date Oct. 13, 1994This invention relates to new bifunctional chelating agents with intermittent chalcogen atoms, pharmaceuticals containing these compounds, their use in radiodiagnostics and radiotherapy, and methods for the production of these compounds. The compound according to the invention has the general formula (I)M-Lwhere M represents a radionuclide and L a ligand of the general formula (II). It was found, surprisingly, that these new, bifunctional chelating agents with intermittent chalcogen atoms and their coupling products with compounds that accumulate specifically are excellently suited for producing radiopharmaceuticals for diagnostic and therapeutic purposes.