Benzoisothiazole and benzoisoxazole-3-carboxamide derivatives a process for their preparation and their use as medicaments

摘要

The present invention relates to benzisothiazole- and benzisoxazole-3-carboxamides of the formula I CHEM wherein R1 is hydrogen or loweralkyl; R2 is loweralkyl, or a group of the formula CHEM R3 is hydrogen or loweralkyl; A is loweralkylene, a group of the formula -CHR4CH=CHCHR4-, or -CHR4C IDENTICAL CHR4-; R4 is hydrogen or loweralkyl; X is O or S; W is N or CH; Y is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, or trifluoromethyl; Z is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, or trifluoromethyl; n is 1 or 2; wherein the solid line (-) refers to the point of attachment of the group to the indicated member of the formula; the geometric and optical isomers thereof; or a pharmaceutically acceptable salt thereof, useful for the treatment of psychoses, alone or in combination with inert adjuvants.