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A microcrystalline cellulose-based excipient composition solid dosage form pharmaceutical compositions containing the same and methods for the preparation thereof
A microcrystalline cellulose-based excipient composition solid dosage form pharmaceutical compositions containing the same and methods for the preparation thereof
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机译:包含其的微晶纤维素基赋形剂组合物固体剂型药物组合物及其制备方法
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摘要
A microcrystalline cellulose-based excipient having improved compressibility, whether utilized in direct compression, dry granulation or wet granulation formulations, is disclosed. The excipient is an agglomerate of microcrystalline cellulose particles and from about 0.1% to about 20% silicon dioxide particles, by weight of the microcrystalline cellulose, wherein the microcrystalline cellulose and silicon dioxide are in intimate association with each other. The silicon dioxide utilized in the novel excipient has a particle size from about 1 nanometer to about 100 microns. Most preferably, the silicon dioxide is a grade of colloidal silicon dioxide.
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