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Picoliden-4-isonicotino-yl-hydrazone dyhidrate with tuberculostatic activity

机译:具有抑菌活性的Picoliden-4-异烟碱基-吡啶盐酸盐

摘要

The invention relates to the new biological active compound of the hydrazone class, and namely picoliden-4-isonicotino-ylhydrazone dyhidrate, manifesting a tuberculostatic activity, which may be used in medicine.The invention consists in the creation of a new substance: picoliden-4-isonicotino-yl-hydrazone dihydrate, manifesting a tuberculostatic activity in respect of the stem H37Rv Micobacterium tuberculosis.The technical solution of the invention consists in obtaining a new substance with the formula:Its tuberculostatic activity in respect of the stem H37Rv Micobacterium tuberculosis remains at the isoniazid level, and the toxicity comes down 3,7 times.
机译:本发明涉及the类的新的生物活性化合物,即表现出抗结核活性的吡啶并吡啶并吡啶-4-哌啶酮-4-异烟酰胺基-酰基吡啶in酸盐,其可用于医学中。 4-异烟酰胺基-di二水合物,对茎H37Rv结核分枝杆菌表现出抑菌活性。本发明的技术方案在于获得下式的新物质:其对茎H37Rv结核分枝杆菌的抑菌活性仍然存在在异烟肼水平,毒性降低了3.7倍。

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