Plaster containing an active substance for delivery of oestradiol with at least one penetration enhancer, method of producing it and its use

摘要

PCT No. PCT/EP95/00032 Sec. 371 Date Oct. 11, 1996 Sec. 102(e) Date Oct. 11, 1996 PCT Filed Jan. 5, 1995 PCT Pub. No. WO95/19162 PCT Pub. Date Jul. 20, 1995An active substance-containing patch for the controlled release of estradiol or its pharmaceutically acceptable derivatives alone or in combination with gestagens from a backing layer, an active substance-containing reservoir connected thereto and produced by using pressure sensitive adhesives and at least one penetration enhancer, and a removable protective layer is characterized by the fact that the penetration enhancer is selected from substances based on carboxylic acids.