Preparation of (2R, 3S) - 3-benzodiazo-2-hydroxy-3-phenylpropionic acid, 4,10-dioxo-2-α - benzodiazo-5,20-epoxy-1,7-dihydroxi-9-oxo-tax-11-en-13 - α - ILO, trihydrate was prepared

摘要

1. To prepare (2R, 3S) - 3-phenyltoluidamide-2-hydroxy-3-phenylpropionic acid, 4,10-dioxane-2 α - phenoxy-5 β, 20-epoxy-1,7 β - dihydroxi-9-oxo-tax-11-en-13 α - ILO, trihydrate, characterized by crystallized α - hydroxy-2-hydroxy-3-phenyl-propyl ethane, 4 20-epoxy-1,7 beta-dihydroxi-9-oxo-tax-11-en-13 α - ILO was mixed in water and liquid alcohol containing 1 to 3 carbon atoms,Secondly, the low pressure products dried up, and then temporary maintenance was carried out when the relative humidity exceeded 20%. In a particular activity, crystallization occurs in the presence of cholesterol acid, In the other case, the ester produced after disinfection of baccatina III was treated directly in situ, and its hydroxyl effect in - 13 was protected by the protected β - phenyl derivative after disposal.