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Amplifying sequences vectors comprising these sequences and their uses in compositions for the expression of nucleotide sequences in transfected cells therapeutic and vaccine applications
Amplifying sequences vectors comprising these sequences and their uses in compositions for the expression of nucleotide sequences in transfected cells therapeutic and vaccine applications
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机译:包含这些序列的扩增序列载体及其在组合物中用于在转染细胞治疗和疫苗应用中表达核苷酸序列的用途
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摘要
Amplifying sequences, vectors comprising these sequences and their uses in compositions for the expression of nucleotide sequences in transfected cells, therapeutic and vaccine applications.Amplifying sequences showing a homology of at least 90% with the following SEQ ID N° 1 sequence:TCTATAAATA X1X2X3GC Y1Y2Y3GG TATTTGGGGT TGGCAGCTGT T in which:X1, X2 and X3 may independently represent respectively C or G, C or G, and C or AY1, Y2 and Y3 may independently represent respectively T or C, C or G, and T or C.Such sequence may included in a sequence or expression vector containing in addition a sequence coding for a protein and a promoter.Such sequences allow very strong amplification of the transcription of the gene coding for the protein.
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机译:扩增序列,包含这些序列的载体及其在组合物中用于在转染细胞,治疗和疫苗应用中表达核苷酸序列的用途。扩增序列与以下SEQ ID N°1序列具有至少90%的同源性: TATTTGGGGT TGGCAGCTGT T,其中:X1,X2和X3可以分别代表C或G,C或G,并且C或AY1,Y2和Y3可以分别代表T或C,C或G和T或C.序列或表达载体中可包含的蛋白质可另外包含编码蛋白质和启动子的序列。这种序列允许非常强地扩增编码蛋白质的基因的转录。
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