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METHOD FOR PRODUCING BIOLOGICALLY ACTIVE BOVINE AND PIG GROWTH HORMONES AND MIXTURE WITH BIOLOGICALLY ACTIVE PIG GROWTH HORMONE
METHOD FOR PRODUCING BIOLOGICALLY ACTIVE BOVINE AND PIG GROWTH HORMONES AND MIXTURE WITH BIOLOGICALLY ACTIVE PIG GROWTH HORMONE
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机译:用生物活性猪生长激素生产生物活性牛和猪生长激素及其混合物的方法
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摘要
A method for preparing polypeptides in bacteria with an alanine rather than a methionine at the N-terminus. The DNA sequence expressed has an alanine codon immediately following from at least one methionine codon, and allows for the expression of polypeptides having the amino acid sequence essentially the same as such naturally occurring eucaryotic protein as various bovine and porcine somatotropin species. In another important embodiment, the invention provides a class of compositions comprising certain valine-containing somatropin species which increase milk production in lactating mammals to a significantly greater extent than otherwise-identical leucine somatotropin species.
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